The brain is made up of groups of neurons which are responsible for certain tasks. Near the center of the brain is a system called the "reward pathway": its job is to transfer dopamine and create the feeling of pleasure. Recreational drugs work by mimicking the brain's inhibitory and excitatory proteins and abusing this pathway to create a "high" in the user.
These drugs have consequences; they affect the reward pathway's ability to create pleasure and wire other parts of the brain, creating an impulse to continue using a drug (i.e. addiction).
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